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Sociological studies demonstrate that age of pregnancy is on the rise in the normal population. Postponing marriage at a later age, the increase of women in the paid workforce, and the prioritization of career plans cause increasingly more pregnancies to at later ages. Scientific studies show that especially some medical problems are experienced more commonly in pregnant women older than 40 years old. According to Turkish Statistical Institute; the average age of mothers, who gave birth in 2001 was 26.7 years while it was 28.9 in 2019. The average age of mothers, who had their first birth in 2019, was 26.4 years.

• High blood pressure during pregnancy
• Diabetes during pregnancy (gestational diabetes)
• Low birth weight baby
• Increased risk of pregnancy loss

Therefore, close monitoring of pregnant women older than 40 years for these risks is necessary whether pregnancy occurred naturally or via assisted reproduction treatment.

If candidate mothers under the age of 35 cannot achieve pregnancy despite unprotected sexual intercourse for a year, the couple should apply to a fertility specialist obstetrician and gynecologist. If the candidate mother over the age of 35 cannot achieve pregnancy for six months despite unprotected sexual intercourse, the couple should be evaluated at the assisted reproduction treatment center.

Unfortunately, women with absolute absence of menstrual periods have no chance of becoming pregnant. Assisted reproduction treatment starts on the second to third days of the menstrual bleeding. Menstrual bleeding is essential to establish pregnancy via assisted reproductive techniques. Provided that medications induce menstruation, there is a chance with assisted reproduction treatment when ovarian stimulating hormones do not work or menstrual cycles are absent. In women with a low egg reserve leading to premature menopause, it is impossible to achieve pregnancy by using the patient's own eggs.